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Effetto del consumo quotidiano di yogurt arricchito con probiotici, sulla resistenza all’insulina nelle donne in gravidanza: uno studio controllato randomizzato

Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial

Z Asemi, M Samimi, Z Tabassi, M Naghibi Rad, A Rahimi Foroushani, H Khorammian and A Esmaillzadeh



Owing to excess body weight and increased secretion of inflammatory cytokines primarily during the third trimester,pregnancy is associated with elevated insulin resistance. To our knowledge, no report is available indicating the effectsof probiotic yoghurt consumption on serum insulin levels in pregnant women. This study was designed to determinethe effects of daily consumption of probiotic yoghurt on insulin resistance and serum insulin levels of Iranian pregnantwomen.


In this randomized controlled clinical trial, 70 primigravida pregnant women with singleton pregnancy at their thirdtrimester were participated. We randomly assigned participants to consume 200g per day of conventional (n=33) or

the probiotic group (n=37) for 9 weeks. The probiotic yoghurt was a commercially available product prepared with thestarter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus, enriched with probiotic culture of twostrains of lactobacilli (Lactobacillus acidophilus LA5) and bifidobacteria (Bifidobacterium animalis BB12) with a total ofmin 1 × 107colony-forming units. Fasting blood samples were taken at baseline and after 9-week intervention tomeasure fasting plasma glucose and serum insulin levels. Homeostatic model assessment of insulin resistance (HOMAIR) was used to calculate insulin resistance score.


Although consumption of probiotic yogurt for 9 weeks did not affect serum insulin levels and HOMA-IR score,

significant differences were found comparing changes in these variables between probiotic and conventional yogurts

(changes from baseline in serum insulin levels: +1.2±1.2 vs +5.0±1.1μIU/ml, respectively, P=0.02; and in HOMA-IR

score: −0.2±0.3 vs 0.7±0.2, respec@vely, P=0.01).


It is concluded that in contrast to conventional yogurt, daily consumption of probiotic yogurt for 9 weeks maintains

serum insulin levels and might help pregnant women prevent developing insulin resistance. eed to be The Journal of Nutritional Biochemistry 2013, 24:1-5